Week 16 NFL betting presents a mix of narrow and wide spreads, with six games featuring odds of a field goal or less and five with spreads of a touchdown or more. Notable matchups include the Philadelphia Eagles facing the Washington Commanders and the Green Bay Packers hosting the New Orleans Saints as a significant favorite.

The SportsLine model, which has shown impressive results, provides predictions and betting advice for all matchups. It has a strong track record, including a 27-11 hot streak this season.